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Advances on immune-related adverse events associated with immune checkpoint inhibitors

Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 33-42 doi: 10.1007/s11684-019-0735-3

Abstract: Immunotherapy has recently led to a paradigm shift in cancer therapy, in which immune checkpoint inhibitorsnon-specific activation of effector T cells, ICIs are remarkably associated with a substantial risk of immune-related

Keywords： cancer     immunotherapy     immune checkpoint inhibitors     immune-related adverse events     review    

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The ecological system and the regionalization of landscape reconstruction in northwest of China

Peicheng LI,Guoyuan DU,Qilei LI,Jinfeng WANG,Feimin ZHENG

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 4,   Pages 291-298 doi: 10.15302/J-FASE-2014033

Abstract: government is strengthening research on improvement and reconstruction of the ecological system and landscapeIt is suggested that the reconstruction of landscape should be conducted by step by step regionalizationThe first level regionalization results of reconstruction of landscape are discussed.

Keywords： reconstruction of landscape     ecological system     the northwest area of China     science and technology action    

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Research on a quantificational method for chromatic-light emotions of architectural wall coatings in landscape

Ting WANG, Ma JIAN, Gang LIU, Xiaoxi LIU, Mingyu ZHANG

Frontiers of Structural and Civil Engineering 2010, Volume 4, Issue 4,   Pages 498-502 doi: 10.1007/s11709-010-0096-0

Abstract: the laws of light cognitive impact and the solution to the problem on application of light color in landscapeThis paper took chromatic-light-induced-emotion towards architectural wall coatings in landscape as the, the study successfully extracted light emotional factors and the rule of predictability to assist landscape

Keywords： landscape illumination     architectural wall coatings     chromatic-light emotion     quantitative research    

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Natural killer cells in liver diseases

Meijuan Zheng, Haoyu Sun, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 269-279 doi: 10.1007/s11684-018-0621-4

Abstract: NK cell activation, well known for its role in the immune surveillance against tumor and pathogen-infectedUnder the setting of liver diseases, NK cells are of great importance for stimulating or inhibiting immuneresponses, leading to either immune activation or immune tolerance.

Keywords： natural killer cell     phenotype     immune activation     immune tolerance     liver diseases    

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FLOWERING PLANTS AND ENTOMOPHAGOUS ARTHROPODS IN THE AGRICULTURAL LANDSCAPE: A PRACTISE-ORIENTED SUMMARY

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 1,   Pages 63-74 doi: 10.15302/J-FASE-2021427

Abstract:

There is a growing demand for high-quality agricultural products and more countries have adopted landscape

Keywords： ecosystem services / flowering plants / natural enemies / nectar / pollen    

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Persistence of humoral and cellular immune response after SARS-CoV-2 infection: opportunities and challenges

Tangchun Wu

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 816-819 doi: 10.1007/s11684-020-0823-4

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of texture and irrigation on the soil moisture vertical-temporal variability in an urban artificial landscape

Xiaofeng ZHANG,Xu ZHANG,Guanghe LI

Frontiers of Environmental Science & Engineering 2015, Volume 9, Issue 2,   Pages 269-278 doi: 10.1007/s11783-014-0672-y

Abstract: Soil moisture variability in natural landscapes has been widely studied; however, less attention has been paid to its variability in the urban landscapes with respect to the possible influence of texture stratification and irrigation management. Therefore, a case study was carried out in the Beijing Olympic Forest Park to continuously monitor the soil in three typical profiles from 26 April to 11 November 2010. The texture stratification significantly affected the vertical distribution of moisture in the non-irrigated profile where moisture was mostly below field capacity. In the profile where irrigation was sufficient to maintain moisture above field capacity, gravity flow led to increased moisture with depth and thus eliminated the influence of texture. In the non-irrigated sites, the upper layer (above 80 cm) exhibited long-term moisture persistence with the time scale approximating the average rainfall interval. However, a coarse-textured layer weakened the influence of rainfall, and a fine-textured layer weakened the influence of evapotranspiration, both of which resulted in random noise-like moisture series in the deeper layers. At the irrigated site, frequent irrigation neutralized the influence of evapotranspiration in the upper layer (above 60 cm) and overshadowed the influence of rainfall in the deeper layer. As a result, the moisture level in the upper layer also behaved as a random noise-like series; whereas due to deep transpiration, the moisture of the deep layer had a persistence time-scale longer than a month, consistent with characteristic time-scales found for deep transpiration.

Keywords： distribution     moisture temporal variation     texture stratification     irrigation     meteorological forcing     urban landscape    

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Heterogeneity of the tumor immune microenvironment and clinical interventions

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 617-648 doi: 10.1007/s11684-023-1015-9

Abstract: Heterogeneity of the tumor immune microenvironment and clinical interventions

Keywords： Heterogeneity tumor immune    

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Molecular classification and precision therapy of cancer: immune checkpoint inhibitors

Yingyan Yu

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 229-235 doi: 10.1007/s11684-017-0581-0

Abstract: MSI-H status due to dMMR and characterized by increased neoantigen load, which elicits intense host immune

Keywords： molecular classification     precision medicine     pembrolizumab     PD-1/PD-L1     MSI-H    

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nitrogen/phosphorus concentration and hydraulic retention time for bloom control in reclaimed water landscape

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 10, doi: 10.1007/s11783-022-1564-1

Abstract:

● A new model for bloom control in open land scape water was constructed.

Keywords： Reclaimed water landscape     Algal bloom     Nitrogen and phosphorus     Hydraulic retention time     Threshold    

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Analysis of the genomic landscape of primary central nervous system lymphoma using whole-genome sequencing

Frontiers of Medicine   Pages 889-906 doi: 10.1007/s11684-023-0994-x

Abstract: This study aimed to depict the genetic landscape of Chinese PCNSLs.Collectively, this study comprehensively reveals the genomic landscape of newly diagnosed Chinese PCNSLs

Keywords： primary central nervous system lymphoma     whole-genome sequencing     TMSB4X     copy number variation     gene mutation    

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Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected

Xinghua Gao, Hongduo Chen

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 1-5 doi: 10.1007/s11684-014-0309-3

Abstract: instance, fever-range temperature (39β°C to 40β°C) can modulate the activities of immuneCytotoxic temperature (>43β°C) can create an antigen source to induce an anti-tumor immune

Keywords： hyperthermia     HPV     immune response     virus     tumor    

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SARS-CoV-2 variants, immune escape, and countermeasures

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 196-207 doi: 10.1007/s11684-021-0906-x

Abstract: Although many countries have promoted roll-out vaccination, the immune barrier has not yet been fully

Keywords： SARS-CoV-2     COVID-19     vaccine     immune escape     breakthrough     prevention    

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Multi-target combinatory strategy to overcome tumor immune escape

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 208-215 doi: 10.1007/s11684-022-0922-5

Abstract: Immune therapy has become the fourth approach after surgery, chemotherapy, and radiotherapy in cancerMany immune checkpoints were identified in the last decade since ipilimumab, which is the first immuneHowever, fewer people are benefitting from immune checkpoint inhibitor treatment in solid cancers.Along with the characterization of more immune checkpoints, the combinatory treatment of multi-immuneIn this work, the author focuses on the combination therapy of multiple immune checkpoints (does not

Keywords： immune checkpoints     multi-target     immune escape     immune-related adverse events     combination therapy    

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Taking Warning from the Eastern Part Elegant Landscape Maturing Slowly——On Landscape Architectural Development

Meng Zhaozhen

Strategic Study of CAE 2000, Volume 2, Issue 10,   Pages 56-58

Abstract:

Elegant landscape will mature slowly.

Keywords： urbanization process     scenic and historical places     urban parks and gardens    

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Title Author Date Type Operation

Advances on immune-related adverse events associated with immune checkpoint inhibitors

Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang

Journal Article

The ecological system and the regionalization of landscape reconstruction in northwest of China

Peicheng LI,Guoyuan DU,Qilei LI,Jinfeng WANG,Feimin ZHENG

Journal Article

Research on a quantificational method for chromatic-light emotions of architectural wall coatings in landscape

Ting WANG, Ma JIAN, Gang LIU, Xiaoxi LIU, Mingyu ZHANG

Journal Article

Natural killer cells in liver diseases

Meijuan Zheng, Haoyu Sun, Zhigang Tian

Journal Article

FLOWERING PLANTS AND ENTOMOPHAGOUS ARTHROPODS IN THE AGRICULTURAL LANDSCAPE: A PRACTISE-ORIENTED SUMMARY

Journal Article

Persistence of humoral and cellular immune response after SARS-CoV-2 infection: opportunities and challenges

Tangchun Wu

Journal Article

of texture and irrigation on the soil moisture vertical-temporal variability in an urban artificial landscape

Xiaofeng ZHANG,Xu ZHANG,Guanghe LI

Journal Article

Heterogeneity of the tumor immune microenvironment and clinical interventions

Journal Article

Molecular classification and precision therapy of cancer: immune checkpoint inhibitors

Yingyan Yu

Journal Article

nitrogen/phosphorus concentration and hydraulic retention time for bloom control in reclaimed water landscape

Journal Article

Analysis of the genomic landscape of primary central nervous system lymphoma using whole-genome sequencing

Journal Article

Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected

Xinghua Gao, Hongduo Chen

Journal Article

SARS-CoV-2 variants, immune escape, and countermeasures

Journal Article

Multi-target combinatory strategy to overcome tumor immune escape

Journal Article

Taking Warning from the Eastern Part Elegant Landscape Maturing Slowly——On Landscape Architectural Development

Meng Zhaozhen

Journal Article